James Hansen, MD

James E. Hansen, MD is Associate Professor, Radiation Oncology Chief of the Yale Gamma Knife Center, and Co-Director of the Yale Stereotactic Radiosurgery and Body Radiotherapy Fellowship Program at Yale School of Medicine. His clinical practice, research, and teaching focuses on tumors of the central nervous system. The Hansen lab investigates autoimmunity and cancer with the goal of strategically developing cell-penetrating autoantibody variants for use in brain tumor immunotherapy. This program is based on his team’s findings of nucleoside salvage-mediated mechanisms of autoantibody crossing of live cell membranes and the blood-brain barrier and yielded the Deoxymab platform of re-engineered nuclear-penetrating antibodies advancing to glioblastoma clinical trials. Ongoing work in the Hansen lab leverages the ability of these autoantibodies to penetrate live cells through nucleoside salvage to develop new methods for impacting undruggable intracellular targets or intracellular delivery of cargo payloads in the treatment of cancer, autoimmunity, and genetic disease.

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